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Spectrophotometric Determination of Zn(II) in Pharmaceutical Formulation Using a New Azo Reagent as Derivative of 2-Naphthol

Spectrophotometric Determination of Zn(II) in Pharmaceutical Formulation Using a New Azo Reagent as Derivative of 2-Naphthol

Original Research ArticleAug 28, 2020Vol. 21 No. 1 (2021)

Abstract

For the fast investigation of Zn(II) using 2-hydroxy-5-(2-hydroxynaphthalen-1-yl) benzoic acid, a specific novel spectrophotometric technique is suggested in this research. The interaction of the azo reagent with Zn(II) is instantaneous at pH 7, and the absorbance of the solution is stable for more than 24 h. The technique allows zinc levels of 1-18 ppm to be calculated, with a molar absorption of 1.516 x104 l mol-1 cm-1. The suggested method for estimating zinc has been widely applied in many pharmaceutical formulations. The error of the determination does not exceed 4%.

 

Keywords: azo reagent; determination of zinc; spectrophotometry; pharmaceutical preparations

*Corresponding author: Tel.: 07809086646

                                             E-mail: muhaimin.alrufaie@uokufa.edu.iq

References

1
Roohani, N., Hurrell, R., Kelishadi, R. and Schulin, R., 2013. Zinc and its importance for human health: An integrative review. Journal of Research in Medical Sciences, 18(2), 144-157.
2
William, D. R., 1985. Analytical Methods in Human Toxicology. New York: Academic Press.
3
Frassinetti, S., Bronzetti, G., Caltavuturo, L., Cini, M., and Croce, C.D., 2006. The role of zinc in life: a review. Journal of Environmental Pathology, Toxicology and Oncology, 25(3), 597-610.
4
Maeda, M., Kinoshita, T. and Tsuji, A., 1970. A novel fluorophotometric method for determination of hexosamines using pyridoxal and zinc (II) ion. Analytical Biochemistry, 38(1), 121-129.‏
5
Mahanand, D. and Houck, J.C., 1968. Fluorometric determination of zinc in biologic fluids. Clinical Chemistry, 14(1), 6-11.‏

Author Information

Mohauman M. Al-Rufaie*

Department of Chemistry, Faculty of Science, University of Kufa, Najaf, Iraq

Mohauman M. Al-Rufaie*

Ministry of Education, Al-Najaf, Iraq

Mohauman M. Al-Rufaie*

Department of Chemistry, Faculty of Science, University of Kufa, Najaf, Iraq

About this Article

Current Journal

Vol. 21 No. 1 (2021)

Type of Manuscript

Original Research Article

Keywords

azo reagent; determination of zinc; spectrophotometry; pharmaceutical preparations

Published

28 August 2020

DOI

Current Journal

Journal Cover
Vol. 21 No. 1 (2021)

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